GM6 ATTENUATES ALZHEIMER'S DISEASE PATHOLOGY IN APP MICE

March 2, 2019

“GM6 Attenuates Alzheimer's Disease Pathology in APP Mice” has been published online by Molecular Neurobiology on 2/23/2019 (PMID number 30798443). The paper concludes, “Application of GM6 over a 4-month period in young APP/ΔPS1 double-transgenic mice resulted in attenuation in Aβ peptide levels, reduction of inflammation and amyloid load, increased cathepsin B expression, and improved spatial orientation. In addition, treatment with GM6 increased brain NGF levels and tempered memory impairment by ∼ 50% at the highest dose. These data suggest that GM6 may modulate disease-determining pathways at an early stage to slow the histological and clinical progression of AD.”